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The properties and performance of one of the latest silicone hydrogel (SiH) lenses, Biofinity (CooperVision), was reviewed last month.1 This highlighted how, as SiH lenses continue to evolve with newer materials and designs, Biofinity offers a new approach with improvements in comfort, wettability and overall performance relative to some older lens materials and designs. Until recently, few studies have evaluated Biofinity’s clinical performance in daily wear. Therefore, the purpose of this most recent study was to evaluate the lens’ daily wear performance in existing soft CL wearers, in addition to comparing its clinical performance against another SiH, Air Optix (CIBA Vision). Method This was a two-month, single-masked, randomised, bilateral, cross over daily wear evaluation with subjects wearing Biofinity and Air Optix for one month each. The multi-centre study was conducted at seven sites in the UK. Lens details are summarised in Table 1. To prevent bias, subjects were masked to lens type and sponsor and investigators masked to sponsor, although not necessarily lens type since Air Optix incorporates distinctive markings. Subjects were current CL wearers, although not using either study lens. Spherical refraction was between -0.50D and -6.00D, with astigmatic correction 1.00D or less. Visual acuity (VA) 6/9 or better was required in each eye. They had normal eyes, with no evidence of abnormality or disease. Subjects needed a mobile phone to receive and send text messages during the study. Subjects were assessed at baseline when details were taken of habitual lens wear (Table 2). They were fitted with a pair of SiHs, with power closest to vertex-corrected spherical spectacle prescription. Lens performance was assessed after 10-15 minutes; a success- Comparative clinical evaluation of two silicone hydrogel lenses for daily wear Guy Whittaker, Karl Aberdeen and John Rogers provide an overview of a comparative evaluation between silicone hydrogel lens performance and older materials and designs TABLE 1 Lens parameters Biofinity Air Optix Manufacturer CooperVision CIBA Vision Material, water content comfilcon A, 48% lotrafilcon B, 33% Dk/t (@-3.00D) 160 138 Surface treatment None Plasma coating Modulus (MPa) 0.75 1.00 Wetting angle (sessile drop) 30° 60° Diameter/base curve (mm) 8.60 / 14.0 8.60 / 14.2 Centre thickness (mm) 0.08 0.08 Study sphere powers (D) -0.50 to –6.00D (-0.25D steps) Recommended replacement period Monthly Monthly (UK) TABLE 2 Summary of clinical assessments Grading Fitting and dispense Follow-ups Monoc. HCDVA with best vision sphere Snellen to nearest letter X X Subjective visual quality 0-100 scale X X Subjective comfort 0-10 scale X X Comfort by SMS text message to subjects mobile phone during 1 month wear 0-10 scale 4 time-points (8am, 12pm, 4pm & 8pm) on 4 days (3, 7, 13 & 27) Symptoms (dryness, discomfort, foreign body sensation) 0 – 3 scale (0=none, 3 = severe) X Preference Study vs habitual lens; study 1 vs study 2 X Lens handling 0-10 scale X Deposits: White spot deposits Film deposits Yes/no 0-4 scale X PLTF assessment (Keeler Tearscope Plus): Lipid layer Non-invasive tear break-up time 0-4 scale Seconds X Lens fit: Lens Centration Tightness on push-up Overall fit acceptance Post-blink movement Centred, slightly or substantially decentred % 0-4 scale 0-4 X X Slit-lamp examination: Limbal & bulbar hyperaemia Corneal fluorescein staining Conjunctival lissamine green staining Conjunctival lens indentation 0-4 CCLRU scale NEI grading 0-4 CCLRU scale 0-4 scale - X contact lens Monthly 24 | Optician | 02.05.08 opticianonline.net ful fit was greater than Grade 2 overall fit acceptance and VA 6/9 or better. Subjects were issued with Opti-Free Express (Alcon) MPDS, along with instructions on text messaging and recording lens comfort. Lenses were worn daily until the next follow-up appointment, and for a minimum of four hours prior to any appointments, which were two and four weeks after dispensing. The second pair of lenses was issued at the one-month follow-up and the process repeated. Lenses were changed when subjects came in for their follow-up visit; if other replacements were required, only the relevant lens was replaced. Subjects were sent an SMS text message on four separate days after each dispensing at four time-points throughout the day (Table 2), asking them to grade comfort (0-10 scale). The first SMS of each day asked for lens insertion time; the last asked when lenses became uncomfortable. From insertion time and when lenses became uncomfortable, comfortable wearing time was calculated. Comfort responses returned within 1.5 hours of being sent were included in the analysis. Results A total of 51 subjects were enrolled; mean age was 33.5 years and 88 per cent were female. Mean high contrast VA with spectacles was -0.02 logMAR (=6/6); mean spherical refraction was -3.02DS and cylinder -0.35DC. Two subjects were discontinued; one with Air Optix after dispensing due to unacceptable comfort and one after two weeks with Biofinity due to lens intolerance. Habitual contact lenses A majority of subjects (60 per cent) were existing wearers of mid or highwater hydrogels; the remainder wore SiHs. The most common previous lens types were Proclear (18 per cent), PureVision and Acuvue Advance (both 16 per cent). All lenses were frequently replaced, with the most popular being monthly (59 per cent), followed by daily (24 per cent). Mean habitual lens power was -2.91D. Wearing time Mean wearing times (WTs) were 13.7 and 13.6 hours for Biofinity and Air Optix respectively, compared to 12.7 hours with habitual lenses. Mean comfortable WTs were within 1.5 hours of mean WT (12.4 hours with Biofinity and 11.9 hours with Air Optix, at one month); these differences were not statistically significant. However, when comfortable WT was assessed using SMS results, it was longer for Biofinity on day seven (11.0 vs 8.9 hours, P=0.01). Comfort Biofinity was rated more comfortable than Air Optix at five of the 16 time points graded with SMS (Figure 1), with differences between lens types (P<0.0001) and time of day (P<0.0001). End-of-day comfort assessment showed most differences, in particular on days seven, 13 and 27. On day seven, mean comfort scores at 8pm were 8.5 and 8.0 for Biofinity and Air Optix respectively (P=0.04). Comfortable WT was also longer with Biofinity on this day (11.0 vs 8.9, P=0.01). Mean comfort scores at both follow-up visits were also higher with Biofinity (8.7 vs 8.4 at one month), although this was not statistically significant. For SMS comfort data, responses were received from 74 per cent of the 1,584 text messages, although the proportion of subjects responding varied depending on time of day and stage of the study. On Day three, response rate was 63 per cent with Biofinity subjects and 73 per cent with Air Optix subjects at 8am; this increased at 8pm to 80 per cent and 78 per cent respectively. On Day 27, response rates at 8am were 69 per cent and 66 per cent for Biofinity and Air Optix respectively, and 73 per cent and 72 per cent at 8pm. Subjective symptoms After one month there was more ‘discomfort’, ‘redness’ and ‘blurred vision’ with Air Optix. Discomfort was reported with 15 per cent of Air Optix eyes compared with 8 per cent for Biofinity (P=0.01); mild redness affected 7 per cent Air Optix eyes compared with 1 per cent Biofinity (P=0.03); blurred vision affected 16 per cent Air Optix eyes compared with 8 per cent Biofinity (P= 0.05). Vision performance Visual performance was similar with the two lenses. Mean VA with Biofinity was significantly higher than with Air Optix; at the one-month visit, there was a difference of two letters in mean logMAR VAs (0.00 and +0.04 for Biofinity and Air Optix respectively). However, there was a significant differ- Figure 1 Summary of comfort via SMS text messaging Figure 2 Subjective vision quality at 2 weeks and 1 month Average comfort (0-10) Summary of comfort via SMS text messaging 6 9 8 7 10 Day 3 Day 7 Day 13 Day 27 * * * * * * 08:00 12:00 16:00 20:00 08:00 12:00 16:00 20:00 08:00 12:00 16:00 20:00 08:00 12:00 16:00 20:00 Biofinity Air Optix * p<0.05 Subjective vision quality (0-100) 2 weeks 1 month Subjective vision quality at 2 weeks and at 1 month Biofinity Air Optix 0 20 90 80 60 40 10 70 50 30 100 p = 0.02 p = 0.038 Contact Lens Monthly 26 | Optician | 02.05.08 opticianonline.net ence in over-refraction between lenses, where Air Optix wearers needed more minus (mean over-refraction -0.12D vs 0.0D with Biofinity). With the over-refraction in place, there were no differences in VA and normalised VA was within one letter of baseline for both SiHs. Subjective vision quality was graded significantly better with Biofinity at both follow-up visits (Figure 2). Lens fit and handling With both lenses, all fits were judged acceptable at the first trial fit and with no significant differences between them. One subject showed excessive, superior decentration with Air Optix at both follow-up visits. The only difference in fit between lenses was noted at two weeks; Air Optix showed less post-blink movement than Biofinity (2.1 v. 2.3, where 2=optimum, P=0.01), although clinically this difference is minimal. There were no significant differences in subjects’ assessment of handleability. Tear film assessment and deposition There were no significant differences in pre-lens tear film assessment with Biofinity and Air Optix (non-invasive break-up time or lipid layer) at either follow-up visit. Mean break-up times were close to 10 seconds, which is relatively long compared with the normal inter-blink period. After two weeks, 15 per cent of both lens types showed some white spot deposits. The mean number of spot deposits was small (0.36 for Biofinity and 0.45 for Air Optix). The proportion of Biofinity lenses with spot deposits did not increase after one month (Air Optix increased to 19 per cent) and means were still small (0.43 and 0.97 respectively). Around a third of the lenses showed film deposits, although means were again small (0.45 and 0.62 respectively on a 0-4 scale at one month). This lipid film, which tends to be more prevalent in SiH materials, can be helped by ensuring a simple rub and rinse step is implemented. Ocular physiology After one month, reductions in limbal and bulbar hyperaemia and vascularisation were noted with both lenses compared with habitual lenses. There was also a reduction in palpebral hyperaemia with Biofinity. At the one-month visit, limbal and bulbar hyperaemia were significantly greater with Air Optix than Biofinity (Figure 3); limbal hyperaemia was noted in 53 Air Optix lens wearing eyes compared with 40 Biofinity eyes. After one month there was a reduction in total corneal staining with both SiHs compared with habitual lenses, in particular, inferior corneal staining. There were two significant differences in slit-lamp findings at the twoweek visit. Central corneal staining was greater with Air Optix, where six eyes (five subjects) showed staining compared to none with Biofinity (0.07 vs 0.00, P=0.02). Conjunctival lens edge indentation was also greater with Air Optix (0.43 vs 0.25, P=0.02); 34 Air Optix eyes showed some conjunctival indentation compared with 21 Biofinity eyes. Lens preference Subjects expressed a preference for Biofinity compared to their habitual lenses (57 per cent at two weeks, P=0.002, with 19 per cent no preference). There was no preference for Air Optix compared to habitual lenses (50 per cent vs 42 per cent). At the final visit, more subjects expressed a preference for Biofinity compared to Air Optix (50 per cent vs 35 per cent), although this was not statistically significant. Discussion The study demonstrated that Biofinity performed well with existing contact lens wearers for daily wear, and there were significant differences in performance between the two lenses, favouring Biofinity, in particular for comfort, symptoms and ocular physiology. Biofinity tended to give better comfort, especially end of day. Although differences were not evident at follow-up visits, it was convincingly shown from text message results, illustrating the value of this method of data collection. The apparent contradictory findings in comfort between visit and SMS results could be explained by the fact that differences in comfort were not evident until later in the day, whereas follow-up visits were typically conducted after less than six hours wear. Differences in comfort were mirrored with symptoms; with Air Optix, more subjects reported discomfort at one month and there was a greater tendency for end-of-day comfort reduction. The reason for comfort differences is not obvious. Possible clues may lie in greater levels of conjunctival indentation and central corneal staining with Air Optix, which may in part be due to lotrafilcon B’s higher modulus. Several studies have also noted superior comfort with Biofinity compared with lotrafilcon A lenses, however, only one study to date has compared the comfort between Biofinity and lotrafilcon B lenses.2 In this parallel group study, Brennan noted higher average comfort with Biofinity, although this was not statistically significant. Text messaging was a useful addition to normal comfort data collection at follow-up visits with responses to three quarters of the SMS sent. It provided insights into the decline in comfort during the day, and demonstrated a significant difference in comfort performance that was only evident Figure 3 Limbal and bulbar hyperaemia at baseline and 1 month Grading of Hyperaemia (0-4) Baseline 1 month Baseline 1 month Limbal hyperaemia Bulbar hyperaemia Habitual Biofinity Air Optix 0 1 0.2 0.8 0.6 0.4 1.2 p = 0.0006 p = 0.03 02.05.08 | Optician | 27 Contact Lens Monthly opticianonline.net with this method of assessments. Not surprisingly, SMS response rates varied depending on time of day and stage of the study, being higher in evenings and earlier on in the study. Other methods have been used to assess CL comfort between visits, such as using handwritten diaries and emails using a BlackBerry device. Paper diaries have caused concerns with accuracy since it is not known if assessments are rated at the correct times, whereas compliance with electronic diaries has been shown to be high.3 A recent study4 evaluated text messaging for collecting subjective responses, where subjects found reporting comfort via SMS easier than with paper diaries, in particular when recording data at a specific time period. Three quarters of subjects responded within 10 minutes and there was a reduction in retrospective data completion (‘cheating’). Text messaging and email means subjects can only answer once prompted, and response time is recorded, although texting has additional advantages over email. A higher response rate (97 per cent) than in the current study was reported with BlackBerrys, although the method of calculation has not yet been published, so a direct comparison is not possible.5 Although Biofinity showed better visual performance than Air Optix, this appears to be back-vertex power-related rather than optical quality since differences were not evident with spherical over-refraction. This suggests Air Optix may incorporate less minus power than Biofinity, and since VA differences were present at dispensing it cannot be due to a CL-induced refraction change. Both single base curve lenses proved versatile since they all successfully fitted a wide range of eyes with similar fitting characteristics between lenses. This contrasts with one of the first generation silicone hydrogel, Night & Day, which with its relatively high modulus requires two base curves for optimal fitting.6 Slit lamp findings were consistently graded lower (in other words, better) at the final visit compared to baseline. Most of these can be explained by being refitted with high oxygen transmissibility lenses. The few differences between lenses were in favour of Biofinity, although these should be regarded with caution since they were not consistent between two follow-up visits. The reduction in limbal and bulbar hyperaemia was in no doubt due to the increase, for most, in lens’ oxygen transmissibility. This effect has been noted by many studies evaluating the effect of refitting with SiHs.7 Reductions in corneal staining were most commonly seen inferiorly and temporally. One likely explanation with former conventional hydrogel wearers is a reduction in desiccation staining with the SiH. For those existing SiH wearers, it is possible that refitting with a lower modulus, highly wettable materials such as comfilcon A combines to reduce corneal insult. The greater levels of hyperaemia seen with Air Optix were unexpected; the two lenses have similar oxygen transmissibilities but the differences could be related to other significant differences, that is central corneal staining and conjunctival indentation. Taken with the reduced comfort levels noted earlier, lotrafilcon B’s greater modulus could lead to greater mechanical pressure and subsequent ocular insult and discomfort in some wearers, although this explanation would be more convincing if differences in slit lamp findings had been consistent between visits. Conclusions This study shows that Biofinity lenses performed well with regards to clinical performance when refitting existing CL wearers for DW. When comparing the lens with another SiH, both performed well, although Biofinity gave better comfort performance than Air Optix, particularly later in the day, along with fewer symptoms of discomfort and blurred vision. The study also demonstrated the benefit of SMS text messaging as an way of assessing lens comfort performance. Biofinity led to fewer slit lamp findings than habitual lenses for limbal hyperaemia, bulbar hyperaemia and corneal staining during the month, in addition to less limbal and bulbar hyperaemia than with Air Optix. References 1 Whittaker G. Biofinity silicone hydrogels. Optician, 2008; April 4. 2 Brennan N, Coles C and Ang J. An evaluation of silicone hydrogel lenses worn on a daily wear basis. Clin Exp Optom, 2006; Jan 89(1): 18-25. 3 Stone A, Shiffman S, Schwartz JE, Broderick JE, Hufford MR. Patient non-compliance with paper diaries. BMJ, 2002; 324: 1193-1194. 4 Morgan P, Maldonado-Codina, Chatterjee N, Moody K. Elicitation of subjective responses via SMS (text) messaging in contact lens clinical trials. Poster presentation, AAO Conference October 2007. 5 Woods C, German T, Dong G, Fonn D. The assessment of contact lens symptomology using wireless hand-held communication devices. AAO Conference 2006. 6 Dumbleton KA, Chalmers RL, McNally J, Bayer S, Fonn D. Effect of lens base curve on subjective comfort and assessment of fit with silicone hydrogel continuous wear contact lenses. Optom Vis Sci, 2002; 79: 633-7. 7 Maldonado-Codina C, Morgan PB, Schnider CM, Efron N. Short-term physiologic response in neophyte subjects fitted with hydrogel and silicone hydrogel contact lenses. Optom Vis Sci, 2004; Dec 81(12): 911-21. Guy Whittaker is global category director of silicone hydrogel products at CooperVision |
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its a pdf file, i provided the URL, but somebody got lazy and didnt want to follow it so i copied and pasted the whole article.
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In your original posting you just put up a link with the title "Biofinity is Better." There must have been something in this PDF file that convinced you of that. What might that be? Was it the PLTF Assessment? The non-invasive tear break-up time? Or maybe it was the conclusion that "Biofinity led to fewer slit lamp findings than habitual lenses for limbal hyperaemia, bulbar hyperaemia and corneal staining"? |
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i got 6 trial lens from walmart OD, one of the lens is just messed up, its blurry near vision but not far, biofinity doesnt have multifocal, so there isnt a problem with that mix up, but i put the lens on either eye and its blurry near, do i dumped the lens and opened another one. the lens seems to get easier to insert/remove/handle as time goes on, at first, right out of blister pack the modulus seemed lower than oasys, but now after 5 days, the modulus of biofinity seems about equal to oasys, even though clinical lab reports show modulus slightly higher for biofinity, which i would not agree with at this point.
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Thanks for explaining all that rfriel. Let me see if I got this straight. Low modulus = floppy lens. High modulus = rigid lens, right? How is modulus measured? What would be a "medium" modulus?
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Obviously you know quite a bit about contact lenses, rfriel. There may be some opticians who are reading this forum, but do you think the average Lens 101 reader will be familiar with terms such as "Mega Pascals"? Maybe it's just me. Jurassic Mark asked what a "medium" modulus would be, and I, for one, still don't know. Maybe I'm just dumb as a brick. ![]() |
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Do you understand what "limbal hyperaemia" is, `cause I don't and I'll wager that most of the people reading this forum don't know either. In this world of instant coffee, microwave ovens and 1-minute reviews, people in general don't want to take the time to look up all the medical jive, they just want the bottom line. Hence the name "Lens 101" as in "introductory course." Am I right, people? That's how I feel, anyway. |
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knotlob |
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A writer effectively communicates when readers are able to comprehend and understand what's written. An individual reader might, occasionally have to look up the meaning of a word. The writer is doing a poor job if the majority of readers don't understand what's written.
A writer has done a poor job if many readers have to look up the meanings of words. You should be writing for your audience. Cut and pasting an entire article may violate copyright. A poster who wants to be helpful would summarize the article, using language the readers can comprehend. |
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Not to mention the fact that the posted article does not have the correct margins, so it takes up a lot more vertical space than necessary. |
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Shame on you, Droopy. ![]() |
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Woah! Translation, please!
I noticed that in this article that some sentences seem incomplete. For example, I found "Lens performance was assessed after 10-15 minutes; a success-" and right at the end "However, there was a significant differ-" Has anyone gotten any important information from this copied and pasted article? Has anyone read the whole thing from start to finish? ![]() Last edited by Admin; 06-29-2010 at 04:55 PM.. Reason: Quote length exceeded |
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When I got my new prescription for contacts, the first one my doctor gave me to try out was Biofinity 30 days. I really liked it because of the awesome optics but I soon realized that it was really drying out my eyes. Anytime I took a nap on them, I would wake up with really uncomfortable eyes. So I went to the doc again to talk to him about this issue. He recommended that I try out the 2 weeks instead of 30 days because it's thinner so pulls in less water from the eyes, thus keeping them "wet". I tried that for a while and at first it was amazing. It was so easy to put on and when it was on my hand I could barely see it. But the problem with the dry eyes stayed but to a lesser extent. So recently I picked up the Air Optix from Ciba vision to see if it is any better. And I gotta say, comfort wise it's much better. I took a nap in them and I woke up without any discomfort in my eyes. I wanted to sleep on them one night but decided against it. Maybe I should try it to see if it's okay.
One thing I should mention even though I have no tangible proof that there is any validity to I will say. I think Biofinity might have better optics than both the 2 weeks version and the Air Optix lens. But this may be just in my head. |
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I guess that's what you get for being lazy, Droopy.
![]() Speaking of lazy--did anybody here read that entire article from beginning to end? Me neither. So why did rfriel post it? Last edited by Admin; 06-29-2010 at 04:56 PM.. Reason: Quote length exceeded |
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What was the name of the 2 week lenses you tried? Is it Biomedics 2, because otherwise it sounds like you had both a Monthly and a Two Week Version of the Biofinity Lens. I've never seen a 2 week Biofinity Lens for sale anywhere, nor seen it mentioned on the Internet. Glad you found comfort in the Air Optix lenses. knotlob |
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Hope that helps. |
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The Biomedics 55 are made of Ocufilcon D whereas the Biofinity lenses are made of Comfilcon A. The Biofinity lenses are about 6.5 times more oxygen breathable than the Biomedics 55. Let us all know how you get on please. knotlob |
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Before you sleep in them, though, it's best to ask your eye doctor first. I don't see why it would be a problem, but I'm not a doctor. Just makes sure you have the "all clear" first. Enjoy those contacts! |
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That's a very good question. I will be sure to ask my Doctor next time I see him. He specifically told me that it was Biofinity, wth? I just kinda assumed there weren't much difference. I am really sorry to mislead you guys. I will find out what they really were. Sorry. |
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Sometimes it is difficult to pick up all the information given out when visiting the doctor or optician, especially if not familiar with the technical terms. knotlob |
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Have fun with your new contacts, JayZ. |
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Keep is posted, okay, JayZ? |
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Since I still had my biofinity lenses from wearing them only two weeks, I decided to put them on again just to try it. It felt so much lighter than the AirOptix. And when they are in the solution, I couldn't even tell if there were any contacts in there. I tried biofinity 30 days for a couple of days and realized that the difference between AirOptix and Biofinity is only very slight in terms of comfort. But for whatever reason, I have this feeling that I see better with biofinity. So I went back to my doctors office and picked up the Biofinity lenses that were left for me. So far, I am enjoying them greatly. I have nothing against AirOptix and I can gladly recommend them to someone but since I already bought one year supply of Biofinity, I am inclined to say that I made the right decision. As for the 2-week lenses I was wearing for a while, I still have no idea what they were (Avaira May be). But I don't particularly care that much to find out. |
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Hope to year more from you soon. |
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No, I didn't read the whole thing either. I just scrolled down to find then end of it and by the time I'd scrolled three or four times I'd decided the article was too long. I suspect others have done the same thing. |
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Dis S d gNR8N dat sends txt msgs dat l%k thus--and you want us to scan this big long ten-page article full of technoblabble to find the answer to Droopy's question which, by the way was . . . well, now I forgot the question.
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Ask, and ye shall receive. I have a admit, that article--while informative--was very, very long. |
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There's a lot to be said about simply telling your own story in your own words.
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That's a rather interesting picture, Sandi. It looks like the chalkboard from a math classroom, but then right below it are clothes on hangers and a pink sign that says "sale." Did some math geek find what looked like a chalkboard at the Gap and decide to get cute?
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Acuvue Oasys are made of Senofilcon A. Biofinity are made of Comfilcon A. Biofinity lenses are a bit more breathable (higher Dk) than Oasys and Avaira lenses. Seems like the Avaira just suit you better. knotlob |
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One might get the impression that rfriel doesn't know what that article says either. He/She probably just copied and pasted it without knowing what it actually says.
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